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Glucagon-like peptide-1 receptor agonists, commonly referred to as GLP-1s, have moved rapidly from medical treatment to mainstream conversation

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If truly non-responsive to GLP-1 therapy, non-GLP-1 alternatives like phentermine-topiramate or the upcoming amylin-based therapies work through different mechanisms that may be more effective for your specific biology

Semaglutide (known by brand names like Ozempic and Wegovy) is a GLP-1 receptor agonist that mimics the body's natural GLP-1 hormone to reduce appetite, slow gastric emptying, and create a prolonged feeling of fullness